State of the Science of Endocrine Disruptors
نویسندگان
چکیده
منابع مشابه
State of the Science of Endocrine Disruptors
(International Programme on Chemical Safety 2002). Over the past decade there have been significant advances in our understanding of endocrine disrupting chemicals (EDCs): their numbers, mechanisms of action, biological effects, and impacts on human and wildlife health. First, as described in the new report (WHO/UNEP 2013), the convergence of wildlife, laboratory animal, and epidemiology data s...
متن کاملترجمه و نقد کتاب the justification of science and the rationality of religious belife
چکیده ندارد.
15 صفحه اولEndocrine Disruptors
Law and science combine in the estimation of risks from endocrine disruptors (EDs) and actions for their regulation. For both, dose–response models are the causal link between exposure and probability (or percentage change) of adverse response. The evidence that leads to either regulations or judicial decrees is affected by uncertainty and limited knowledge, raising difficult policy issues that...
متن کامل[Endocrine disruptors: mechanism of action].
<要 約> 内分泌撹乱化学物質, いわゆる 「環境ホルモン」の生体作用の特徴, その対象 として想定され ている化学物質, ならびに現時点での問題点について概説 した.“内分泌ホルモン様の機能”を もつ化学物質 としてのこれ らの物質の生体作用の特徴は, 受容体原性の作用 に性質が集約 される. そこにある問題点は, まず第1に 閾値問題, すなわち受容体原性の障害発症機構に起因する極微量反応性の問題, 第2に 低用量問 題, すなわちおそらく受容体のリダンダンシーなどの分子機構 に関わると思われる, 低用量域ではっきりし ない用量相関問題, 第3に 受容体 シグナルの伝達機構に関わる 「相乗 ・相加効果」の問題, そ して, 第4に, 胎生期の特定な時期に高い感受性 を呈 して後世代影響へ とつながる, いわゆる 「胎生期ウィンドウ」の問題 である. この他, 受容体のプレイオ ト...
متن کاملModeling the Demographic Effects of Endocrine Disruptors
In this article we describe a series of strategic models of populations and individuals subject to challenge by endocrine disruptors. These models are not designed to be fitted to detailed data on specific species but rather are intended to provide general insights on the relative importance of different demographic mechanisms in the population context. Therefore, the models contain the minimum...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2013
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.1306695